Study on adsorption of ten injectable drugs by eight kinds of disposable filter membranes for infusion apparatus / 中国药学杂志
Chinese Pharmaceutical Journal
; (24): 634-638, 2012.
Article
in Zh
| WPRIM
| ID: wpr-860764
Responsible library:
WPRO
ABSTRACT
OBJECTIVE:
To investigate the absorbability of 8 kinds of disposable filter membranes for infusion apparatus to 10 injectable drugs, thus to provide information for clinical medication.METHODS:
Each drug was separately dissolved in 250 mL 5% dextrose solution. Samples of drug solutions were collected before and after being filtered by the membranes. These samples were analyzed by HPLC-MS/MS methods.RESULTS:
The 8 kinds of membranes had different adsorbabilities to the 10 injectable drugs. CN-CA membrane (CN-CA) and CN-CA Enhance membrane (CN-CA-E) adsorbed more drugs than other membranes (P<0.05). The average adsorption of PES membrane, NL-B membrane and ION membrane to the 10 drugs were lower than 1%. PP membrane and NL membrane to the 10 drugs were lower than 1.5%.CONCLUSION:
PES membrane, ION membrane and NL-B membrane have lower adsorbabilityies than other membranes, thus may have little influence on medical treatment. They may be suitable for clinical application. Copyright 2012 by the Chinese Pharmaceutical Association.
Full text:
1
Database:
WPRIM
Language:
Zh
Journal:
Chinese Pharmaceutical Journal
Year:
2012
Document type:
Article